专业监测看板

ARrest RESpiraTory Failure From PNEUMONIA

药物 / 成分：Inhaled budesonide and formoterol、Inhaled placebo

登记的停止原因（原文）：Per DSMB's review of interim analysis, the study has reached the pre-specified futility criteria

Treosulfan-Based Versus Clofarabine-Based Conditioning Before Donor Hematopoietic Stem Cell Transplant for the Treatment of Myelodysplastic Syndromes or Acute Myeloid Leukemia

药物 / 成分：Clofarabine、Fludarabine、Hematopoietic Cell Transplantation、Total-Body Irradiation

登记的停止原因（原文）：The study was closed due to the end of funding.

A Phase 1 Clinical Study of NXP800 in Subjects With Advanced Cancers and Expansion in Subjects With Ovarian Cancer

药物 / 成分：NXP800

登记的停止原因（原文）：Study terminated due to various reasons impacting the feasibility of future clinical development

Effects on Postoperative Pain of Liposomal Bupivacaine in Interscalene Blocks for Total Shoulder Arthroplasty Patients

药物 / 成分：Liposomal bupivacaine、Bupivacaine

登记的停止原因（原文）：Due to resource limitations and the lack of difference observed between study groups after the interim analysis, the study was halted prematurely.

SHR-4602 for Injection in Subjects With HER2-expressing or -Mutated Unresectable or Metastatic Solid Tumors

药物 / 成分：SHR-4602

登记的停止原因（原文）：The adjustment of the sponsor's R\&D strategy.

A Phase 2, Open-Label, Extension Study to Evaluate Long Term Safety and Clinical Activity of Briquilimab in Participants From Jasper-Sponsored Chronic Urticaria Trials

药物 / 成分：Briquilimab

登记的停止原因（原文）：Sponsor Decision - terminated due to changes in company priorities and not related to safety concerns.

Remedial Mechanism of Simvastatin and Ursodeoxycholic Acid in Liver Cirrhosis: Crosstalk of Bile Secretion, Gut Microbiome, and Host Immune Response

药物 / 成分：Ursodeoxycholic Acid (URSO)、Simvastatin

登记的停止原因（原文）：Slow recruitment and exhaustion of available study funding.

Vaccination of Patients With Ovarian Cancer With Dendritic Cell/Tumor Fusions With Granulocyte Macrophage Colony-stimulating Factor (GM-CSF) and Imiquimod

药物 / 成分：GM-CSF、Dendritic Cell/Tumor Fusion Vaccine、imiquimod

登记的停止原因（原文）：Withdrawal of funding

A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1468 in Healthy Adults ≥50 Years of Age

药物 / 成分：mRNA-1468、Placebo、Shingrix

登记的停止原因（原文）：The clinical study was terminated prior to the start of Phase 2 following a business decision to discontinue further development of the vaccine.

Randomized, Double-blind Study of Efficacy and Safety of Bexotegrast (PLN-74809) for Idiopathic Pulmonary Fibrosis

药物 / 成分：PLN-74809、Placebo

登记的停止原因（原文）：DSMB recommendation

Study to Evaluate the Safety and Efficacy of GSK1278863 in Recombinant Human Erythropoietin (rhEPO) Hyporesponsive Hemodialysis-dependent Chronic Kidney Disease Subjects With Anemia

药物 / 成分：GSK1278863、Placebo

A Study to Evaluate Efficacy, Safety, and Tolerability of Alemtuzumab in Pediatric Patients With RRMS With Disease Activity on Prior DMT

药物 / 成分：Alemtuzumab GZ402673、Glatiramer acetate、Beta-Interferon、Methylprednisolone

登记的停止原因（原文）：Enrolment formally closed earlier than planned due to recruitment challenges.

A Phase II Study of Nivolumab + Ipilimumab in Advanced HCC Patients Who Have Progressed on First Line Atezolizumab + Bevacizumab

药物 / 成分：Ipilimumab、Nivolumab

登记的停止原因（原文）：Sponsor has withdrawn support for the study.

Propranolol Hydrochloride in Treating Patients With Prostate Cancer Undergoing Surgery

药物 / 成分：Laboratory Biomarker Analysis、Propranolol Hydrochloride、Questionnaire Administration、Survey Administration

登记的停止原因（原文）：PIs not interested in continuing with the trial.

A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer)

药物 / 成分：5-Fluorouracil (5-FU)、Leucovorin、Oxaliplatin、Atezolizumab

登记的停止原因（原文）：The study was closed because the sponsor decided not to continue the development of certain treatment combinations.

Subsequent Line Gemcitabine and Nivolumab in Treating Participants With Metastatic Small Cell Lung Cancer

药物 / 成分：Gemcitabine、Nivolumab

登记的停止原因（原文）：After interim analysis decided not to move forward with continuing the trial.

A First Time in Human (FTIH) Study of GSK3745417 Administered to Participants With Advanced Solid Tumors

药物 / 成分：GSK3745417、Dostarlimab

登记的停止原因（原文）：Business Decision

Solriamfetol in Improving Sleep in Patients With Grade II-IV Glioma

药物 / 成分：Soliramfetol

登记的停止原因（原文）：Axsome has conducted a review of the ongoing IST program and are unable to continue supporting this study

Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and Combinations in Patients With Urothelial Carcinoma (MORPHEUS-UC)

药物 / 成分：Atezolizumab、Enfortumab Vedotin、Niraparib、Magrolimab (Hu5F9-G4)

登记的停止原因（原文）：Study was closed early as the sponsor decided not to continue development of certain treatment combinations.

Effect of Fecal Microbiota Transplantation (FMT) in Pediatric Functional Gastrointestinal Disorders

药物 / 成分：FMT、Conventional drugs

登记的停止原因（原文）：The study was terminated early because recruitment of eligible children with refractory functional abdominal pain disorders was slower than anticipated, and enrollment of the planned 50 participants was not feasible within the approved study period.